The stage is set for some space history to be made tonight as two veteran NASA astronauts aim to launch in a spacecraft that has never flown with humans before.

Butch Wilmore and Suni Williams will climb aboard Boeing's CST-100 Starliner capsule and lift off atop a United Launch Alliance Atlas V rocket from Cape Canaveral Space Force Station's Space Launch Complex 41 at 10:34 p.m. on the Crew Flight Test (CFT) mission to the International Space Station.

NASA's live coverage of the leadup to launch will begin on NASA TV and its social media channels beginning at 6:30 p.m.

The pair, along with 750 pounds of supplies, would arrive to the station early Wednesday—at 12:46 a.m—to begin an eight-day stay before a return flight home as early as May 15 that would have a primary landing site of White Sands Space Harbor in New Mexico.

"This is a test flight. That brings to bear all the things that the title implies," said NASA Administrator Bill Nelson. "Because it is a test flight, we give extra attention. They're checking out a lot of the systems—the life support, the manual control, all of those things that you want to be checked out.