As we prepare to go deeper into space, the demand for autonomous systems capable of operating independently from ground control and crew interactions is increasing. Artificial Intelligence (AI) is shaping up to be an essential tool for reaching this goal. With support from ESA's Discovery programme, a team of researchers from Airbus explored how AI can collect and analyse data onboard the Columbus module of the International Space Station (ISS) in order to improve its prognosis and fault detection capabilities.