Just last fall, a Russian movie crew flew up, followed by a Japanese fashion tycoon and his assistant.
NASA is finally getting into the act, after years of opposing space station visitors.
"It was a hell of a ride and we're looking forward to the next 10 days," said former NASA astronaut and chaperone Michael Lopez-Alegria on reaching orbit.
The visitors' tickets include access to all but the Russian portion of the space station—they'll need permission from the three cosmonauts on board. Three Americans and a German also live up there.
Lopez-Alegria plans to avoid talking about politics and the war in Ukraine while he's at the space station.
"I honestly think that it won't be awkward. I mean maybe a tiny bit," he said. He expects the "spirit of collaboration will shine through."
The private Axiom Space company arranged the visit with NASA for its three paying customers: Larry Connor of Dayton, Ohio, who runs the Connor Group; Mark Pathy, founder and CEO of Montreal's Mavrik Corp.; and Israel's Eytan Stibbe, a former fighter pilot and founding partner of Vital Capital.
Before the flight, their enthusiasm was obvious. Stibbe did a little dance when he arrived at the launch pad at Kennedy Space Center.
SpaceX and NASA have been upfront with them about the risks of spaceflight, said Lopez-Alegria, who spent seven months at the space station 15 years ago.
"There's no fuzz, I think, on what the dangers are or what the bad days could look like," Lopez-Alegria told The Associated Press before the flight.
NASA's Kathy Lueders, head of space operations, said there's a lot to learn from this first wholly private station visit. "But man, was this launch a great start," she told reporters.
Each visitor has a full slate of experiments to conduct during their stay, one reason they don't like to be called space tourists.
"They're not up there to paste their nose on the window," said Axiom's co-founder and president, Michael Suffredini, a former NASA space station program manager.
The three businessmen are the latest to take advantage of the opening of space to those with deep pockets. Jeff Bezos' rocket company Blue Origin is taking customers on 10-minute rides to the edge of space, while Virgin Galactic expects to start flying customers on its rocket ship later this year.
Friday's flight is the second private charter for Elon Musk's SpaceX, which took a billionaire and his guests on a three-day orbit ride last year. SpaceX's fifth flight of NASA astronauts to the station is coming up in just a couple weeks.
Axiom is targeting next year for its second private flight to the space station. More customer trips will follow, with Axiom adding its own rooms to the orbiting complex beginning in 2024. After about five years, the company plans to detach its compartments to form a self-sustaining station—one of several commercial outposts intended to replace the space station once it's retired and NASA shifts to the moon.
At an adjacent pad during Friday's launch: NASA's new moon rocket, which is awaiting completion of a dress rehearsal for a summertime test flight.
As a gift for their seven station hosts, the four visitors are taking up paella and other Spanish cuisine prepared by celebrity chef José Andrés. The rest of their time at the station, NASA's freeze-dried chow will have to do.
The automated SpaceX capsule and its four passengers are due back April 19 with a splashdown off the Florida coast.
Connor is honoring Ohio's air and space legacy, is bringing along a fabric swatch from the Wright brothers' 1903 Kitty Hawk flyer and gold foil from the Apollo 11 command module from the Neil Armstrong Air and Space Museum in Wapakoneta.
Only the second Israeli in space, Stibbe will continue a thunderstorm experiment begun by the first—Ilan Ramon, who died aboard shuttle Columbia in 2003. They were in the same fighter pilot squadron.
Stibbe is carrying copies of recovered pages of Ramon's space diary, as well as a song composed by Ramon's musician son and a painting of pages falling from the sky by his daughter.
"To be a part of this unique crew is a proof for me that there's no dream beyond reach," he said.
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