SpaceX's all-civilian Inspiration4 crew spent their first day in orbit conducting scientific research and talking to children at a pediatric cancer hospital, after blasting off on their pioneering mission from Cape Canaveral the night before.

St Jude tweeted its patients got to speak with the four American space tourists, "asking the questions we all want to know like 'are there cows on the Moon?'"

Billionaire Jared Isaacman, who chartered the flight, is trying to raise $200 million for the research facility.

Inspiration4 is the first orbital spaceflight with only private citizens aboard.

Earlier, Elon Musk's company tweeted that the four were "healthy" and "happy," had completed their first round of scientific research, and enjoyed a couple of meals.

Musk himself tweeted that he had personally spoken with the crew and "all is well.

SpaceX's all-civilian Inspiration4 crew are "healthy, happy and resting comfortably," the company said Thursday in its first update since the pioneering mission blasted off from Cape Canaveral the night before.

The four American space tourists "traveled 5.5 times around Earth, completed their first round of scientific research, and enjoyed a couple of meals" before going to bed, Elon Musk's company said.

Musk tweeted that he had personally spoken with the crew and "all is well."

After waking up, they will get their first look out of the Dragon ship's cupola—a large observation dome that has been fitted onto the vessel for the first time, in place of a docking mechanism.

Billionaire Jared Isaacman, physician assistant Hayley Arceneaux, geoscientist Sian Proctor and aerospace data engineer Chris Sembroski are orbiting the globe at an altitude that at times reaches 590 kilometers (367 miles).

The Institute of Planetary Research at DLR (German Aerospace Center) is starting construction of a new Sample Analysis Laboratory (SAL) dedicated to the study of rock and dust samples from planetary bodies such as asteroids and the Moon. The first phase will be operational by the end of 2022, on time to welcome samples collected by the Hayabusa2 mission, and fully ready by 2023.