On 15 September 2022, ESA astronaut Samantha Cristoforetti conducted an in-flight call with the European Parliament from the International Space Station. In conversation with President Metsola and ESA Director General Josef Aschbacher, she provided insights into the importance Europe’s presence in space, as well as the scientific and technological progress enabled by its activities. The three also touched on Samantha’s upcoming commandership, life on the Station, and the pressing issue of space debris.